The endocrine pancreas in pyridoxine deficient rats.

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Thyroid function in pyridoxine-deficient young rats.

In pyridoxine-deficient young rats hypothalamic serotonin was decreased with no changes in the dopamine and noradrenaline content. Serum thyroxine and tri-iodothyronine concentrations were much lower in the deficient rats as compared to pyridoxine-supplemented controls. No significant difference between deficient and control groups in the serum TSH concentration was detected. Highly significant...

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Zinc ions in the endocrine and exocrine pancreas of zinc deficient rats.

OBJECTIVE Zinc deficiency is a problem world-wide. Zinc and insulin are intimately related, and a reduced zinc intake may affect glucose metabolism. The present study investigates how subclinical zinc deficiency in rats affects glucose metabolism and zinc distribution in the pancreas. METHODS Glucose metabolism was evaluated by blood-glucose, serum insulin, homeostasis model assessment (HOMA)...

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L-cystathionine in the urine of pyridoxine-deficient rats.

The work of Stefano & Diermeier (1956) on the effect of growth hormone upon the development of polyploidy in the liver is in keeping with the hypothesis that growth hormone is important in the growth ofthe liver. Proof ofthe hypothesis requires work on liver regeneration in hypophysectomized rats. Some preliminary experiments which we have performed gave no positive result, but investigations a...

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Endocrine pancreas in insulin receptor-deficient mouse pups.

Insulin receptor (IR)-deficient pups rapidly become hyperglycemic and hyperinsulinemic and die of diabetic ketoacidosis within a few days. Immunocytochemical analysis of the endocrine pancreas revealed that IR deficiency did not alter islet morphology or the number of beta-, alpha-, delta-, and pancreatic polypeptide (PP) cells. The lack of IR did not result in major changes in the expression o...

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Hypothyroidism of hypothalamic origin in pyridoxine-deficient rats.

Pyridoxine-deficient young rats (3 weeks old) had significantly reduced levels of pituitary TSH, serum thyroxine (T4) and tri-iodothyronine (T3) compared with pyridoxine-supplemented rats. The status of the pituitary-thyroid axis of normal, pyridoxine-supplemented and pyridoxine-deficient rats was evaluated by studying the binding parameters of [3H](3-methyl-histidine2)TRH in the pituitary of t...

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ژورنال

عنوان ژورنال: The Tohoku Journal of Experimental Medicine

سال: 1981

ISSN: 0040-8727,1349-3329

DOI: 10.1620/tjem.134.331